The first isolation and structure identifications of prednisone and prednisolone were done in 1950 by Arthur Nobile .    The first commercially feasible synthesis of prednisone was carried out in 1955 in the laboratories of Schering Corporation, which later became Schering-Plough Corporation , by Arthur Nobile and coworkers.  They discovered that cortisone could be microbiologically oxidized to prednisone by the bacterium Corynebacterium simplex. The same process was used to prepare prednisolone from hydrocortisone . 
After an obnoxious amount of digestive upset, numerous UTI’s and 30+ pounds of weight gain, I have finally significantly reduced my aspartame intake. I made the decision one day after feeling incredibly bloated and gross. I was up to drinking 1-2 can’s of Pepsi Max and 1-2 glasses (equal to 4 servings) of crystal light a day. In addition I chew gum, up to 7 pieces a day. I am now on day 13 of no beverages or foods with aspartame. I still chew the gum as I have not yet found a substitute, but only about 3-4 pieces a day. For me, gum is more of a physical addiction. I need to chew on something. I have replaced my daily beverages with plain water, sparkling seltzer water that is only carbonated water and natural flavors, no other ingredients. When I feel like I want some soda, I drink regular. I don’t really crave pop anymore so I only have maybe 2-3 a week. As for caffeine, I take Green Tea tablets. I am more cautious of ingredients in everything. I never had a weight problem until I used “diet” beverages and foods. This sucks as I now have more than 30 pounds to try and lose.
With prolonged intake, individuals may develop Cushing's syndrome , marked by changes in the redistribution of body fat (leading to buffalo hump, moon face, appearance of abdominal striae), high risk of infections, acne and other skin lesions, osteoporosis (and higher risk of pathological fractures), changes in blood lipid levels and diabetes. Cushing's syndrome generally marks the onset of full-blown physical glucocorticoid dependence. If you are experiencing one or more symptoms of Cushing's syndrome, abrupt cessation may increase the risk of complications. A case study  suggested that people with tuberculosis, asthma and other pulmonary conditions can develop Cushing syndrome within 6 months with a dosage of 30 mg/day.