As soon as the Laboratory Results are matched with a DCF in ADAMS, the Adaptive Model is automatically applied to detect Atypical Passport Findings(ATPFs). The Adaptive Model is an algorithm that calculates whether the result, or results over time in the case of a longitudinal profile, is likely the result of a normal physiological condition. An Atypical Passport Finding (ATPF) is generated in ADAMS if the athlete’s T/E ratio is out of the individual range generated by the Adaptive Model to a specificity of 99%. An Atypical Passport Finding (ATPF) requires further investigation.
In the past several years, some newer medications have come on the market; these are commonly referred to as COX-2 inhibitors . Remember, all NSAIDs work against cyclooxygenase (COX). Traditional NSAIDs (. Ibuprofen, Motrin, Aleve) work against both COX-1 and COX-2. COX-1 and COX-2 are both types of cyclooxygenase enzymes that function in your body. The new medications (. Celebrex) work primarily against COX-2, and allow COX-1 to function normally. Because COX-1 is more important in producing the protective lining in your gut (gastric mucosa), these newer NSAIDs are believed to have less of a risk of causing stomach ulcers.