A topical corticosteroid is considered first-line therapy for patients with oral lichen planus. 15 One controlled trial 17 demonstrated the effectiveness of fluocinonide (Lidex) ointment applied to dried oral mucosa six times daily for nine weeks. The steroid, in an adhesive base, was prepared by the pharmacy, although Orabase has also been recommended as an occlusive vehicle. 4 Other topical medications and systemic therapies have been used to treat patients with oral lichen planus 15 that is corticosteroid-resistant. These therapies include topical cyclosporine, systemic corticosteroids, topical and systemic retinoids and oral PUVA.