Heat shock factor 1 (HSF1) is a transcription factor that is involved in the general maintenance and upregulation of Hsp70 protein expression.   Recently it was discovered that HSF1 is a powerful multifaceted modifier of carcinogenesis . HSF1 knockout mice show significantly decreased incidence of skin tumor after topical application of DMBA (7,12- d i m ethyl b enz a nthracene), a mutagen .  Moreover, HSF1 inhibition by a potent RNA aptamer attenuates mitogenic (MAPK) signaling and induces cancer cell apoptosis . 
Heat stroke is a true emergency that requires immediate recognition and treatment. It is defined by a pathologic elevation of core temperature of 104°F or greater and associated central nervous system disturbances. 6 , 8 , 9 , 13 , 20 Physicians considering the diagnosis of heat stroke should obtain a rectal temperature as soon as possible. Although anhidrosis can occur in classic heat stroke, affected patients may continue to perspire. 9 , 10 , 20 A broad constellation of clinical signs and symptoms can be observed in both forms of heat stroke.