Esteroides intranasales

6 6 J Sastre, et al Table 4. Continued Condition Study N Patient INC Treatment Safety Chervinsky et al, 663 Adolescent and CIC 200 μg QD Up to 1 y No effect on morning plasma cortisol 2007 [31] adult (12-73 y) or 24-h urinary cortisol No difference vs PL in IOP, visual acuity or lens opacification Rosenblut et al, 806 Adolescent and FF 110 μg QD 12 mo No clinically meaningful differences 2007 [34] adult (12-77 y) vs PL in 24-h urinary cortisol excretion or ophthalmic parameters Maspero et al, 558 Children FF 110 μg or 55 μg 12 wk No clinically meaningful differences 2008 [70] (2-11 y) QD vs PL in 24-h urinary cortisol excretion or ophthalmic parameters (IOP, cararact) Tripathy et al, 112 Children FF 110 μg QD 6 wk No significant difference between PL 2009 [71] (2-11 y) and FF in change from baseline in 24-h plasma or urinary cortisol levels following 6 wk of treatment Martinati et al, 39 Children BDP 200 or 2 mo No significant changes from baseline 1993 [72] 400 μg QD in markers of bone metabolism Agertoft and 22 Children MFNS 100 or 2 wk No short-term effects on growth rate Pedersen, 1999 (7-12 y) 200 μg QD or (knemometry) [73] BUD 400 μg QD Skoner et al, 100 Children BDP 168 μg BID 1 y No effect on morning cortisol levels 2000 [36] (6-9 y) or response to cosyntropin; a growthsuppressive response was observed with BDP Schenkel et al, 98 Children MFNS 100 μg QD 1 y No effect on cortisol (cosyntropin 2000 [26] (3-9 y) stimulation) or growth rate (knemometry) Allen et al, 150 Children FP 200 μg QD 1 y No growth changes 2002 [79] (-9 y) Gradman et al, 58 Children FF 110 μg QD 2 wk No short-term effects on growth 2007 [74] rate (knemometry) Ozturk et al, 26 Adults BUD 200 μg BID 3-19 mo No increase in IOP, no cataracts, no 1998 [75] (18-66 y) BDP 200 μg BID changes in visual acuity [p848,col2, par3, 4] Simons et al, 95 Children and BDP or BUD Median: 5 y No posterior subcapsular cataracts 1993 [76] adult (6-25 y) (median dose: (range 1-15 y) 750 μg/d) Cutler et al, 56 Children MFNS 100 μg QD 42 d No significant changes vs PL or 2006 [77] (2-6 y) baseline in serum cortisol or 24-h urinary-free cortisol Fluticasone 249 Children FP 100 or 200 μg QD 4 wk No significant changes vs PL or Propionate Collab (4-11 y) baseline in morning serum cortisol Ped Working Group or 24-h urinary cortisol 1994 [78] Galant et al, 65 Children FP 200 μg QD 6 wk FP equivalent to PL in mean change 2003 [79] (2-3 y) from baseline in 12-h creatininecorrected urinary-free cortisol concentration Vargas et al, 105 Adults FP 200 μg QD or 4 wk No evidence of altered HPA-axis 1998 [80] (18-65 y) FP 400 μg BID response to cosyntropin with either FP dose compared with PL

Esteroides intranasales

esteroides intranasales

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