When activated macrophages start to secrete IL-1, which synergistically with CRH increases ACTH,  T-cells also secrete glucosteroid response modifying factor (GRMF), as well as IL-1; both increase the amount of cortisol required to inhibit almost all the immune cells.  Immune cells then assume their own regulation, but at a higher cortisol setpoint. The increase in cortisol in diarrheic calves is minimal over healthy calves, however, and falls over time.  The cells do not lose all their fight-or-flight override because of interleukin-1's synergism with CRH. Cortisol even has a negative feedback effect on interleukin-1  —especially useful to treat diseases that force the hypothalamus to secrete too much CRH, such as those caused by endotoxic bacteria. The suppressor immune cells are not affected by GRMF,  so the immune cells' effective setpoint may be even higher than the setpoint for physiological processes. GRMF affects primarily the liver (rather than the kidneys) for some physiological processes. 
mg/day inhaled via jet nebulizer either once daily or divided into 2 doses. The maximum manufacturer recommended total dose is 1 mg/day. The National Asthma Education and Prevention Program Expert Panel defines low dose therapy for budesonide inhalation suspension as mg/day, medium dose therapy as 1 mg/day, and high dose therapy as 2 mg/day for children ages 5 to 11 years. Titrate to the lowest effective dose once asthma stability is achieved. Prolonged use of high doses, ., 2 mg/day, may be associated with additional adverse effects.
Google skin clinics near ur area..if u are from south africa like me u can go to Diva Slimming Aesthetics in Sunninghill, they do removal of steetchmarks. Well stretchmarks wont completely go away but atleast they can fade after a few treatments. Bio oil and other stretchmark creams alone, wont help with severe stretchmarks u need laser treatments to get them removed. They charge R1200 for 3 sessions in 1 area for removal of stretchmarks. Bio oil and other creams will only help abit I guess…Steroid creams like epiderm, bethnovate, movate, g&g, diproson, all creams that come with tubes all contain steroids…steroids cause stretchmarks in the long run…hydroquinine products can only be used for a short while if u use hydroquinone for too long, it makes dark patches on ur forehead called ochronosis. Ladies u must google information first for anything u want to do or anything the u!