Overall, 15 of 17 asymptomatic patients (grade 1) were successfully managed by withholding the checkpoint inhibitor, while 2 of the 17 and all 14 with grade 2 pneumonitis were successfully treated with corticosteroids. All 12 patients with grade 3 or higher pneumonitis were initially treated with corticosteroids. Five patients in this group required additional immunosuppression ( infliximab with or without cyclophosphamide ), but all five ultimately died. The median starting dose of prednisone was 50 mg, and the median duration of treatment required was 68 days (range 20 to 154 days).
Addiction to cortisone was the subject of the 1956 motion picture, Bigger Than Life , produced by and starring James Mason . Though it was a box-office flop upon its initial release,  many modern critics hail it as a masterpiece and brilliant indictment of contemporary attitudes towards mental illness and addiction.  In 1963, Jean-Luc Godard named it one of the ten best American sound films ever made.  John F. Kennedy needed to regularly use corticosteroids such as cortisone as a treatment for Addison's disease .